You can reach Zompo Lo Schioppo Nature Reserve from the north with the Highway A25, exit Castello di Avezzano and by taking Superstrada del Liri in direction of Sora: you will reach Morino in 15 minutes.
If you come from the south, take the exit Cassino on the Highway A2, taking then Superstrada del Liri in direction of Avezzano: you will reach Morino in one hour.