Matese Park lies at the crossroads of the main ways of communication of central-southern Italy. The area is served by roads, railway lines, and bus lines; it is therefore easily accessible both by car and public means of transport.
The area is easily accessible by train, above all from Campania. The Alifana Railway Line connects Piedimonte Matese with Naples and several towns of the Volturno valley and Terra di Lavoro with several daily trips. Although the coaches are usually old and slow, the trips are rather frequent. The journey from Naples to Piedimonte Matese lasts about two hours. The most frequent bus runs are carried out by Ferrazza bus line of Piedimonte Matese, by CPTC and CPTC, connecting Matese with the main towns of Campania and Molise.
Matese Park is about 45 km far from Capodichino Airport (Naples).